Public Health Alert: Guinea-Bissau confirmed its first mpox case, with the patient a 27-year-old woman who sought care on June 24; samples were tested locally and then confirmed in Dakar, and authorities have activated national response measures under WHO rules, launched contact tracing, reinforced surveillance at borders, and urged basic prevention like handwashing and avoiding close contact with people showing fever or rashes. Regional Politics: Opposition parties in Guinea-Bissau accuse ECOWAS of bias after a mission led by Sierra Leone’s foreign minister and ECOWAS officials allegedly met only coup authorities while sidelining opposition groups, escalating tensions around a controversial constitutional review. Foreign Policy: Guinea-Bissau reaffirmed support for Morocco’s territorial integrity and its Sahara autonomy plan, highlighting the opening of a consulate in Dakhla and welcoming a UN Security Council resolution endorsing the approach. Health & Development Context: A UN-linked ranking placed Sierra Leone among the world’s lowest life expectancy countries, underscoring ongoing public health and development pressures across the region.